4

biologic research.14 The species is commercially avail-
able, easily handled, and generally more economic and
easier to maintain than the traditional carnivores.


References

1.
Crandall RB, McGreevy PB, Connor DH, Crandall CA, Niel-
son JT, McCall JW: The ferret (Mustela putorius furo) as an
experimental host for Brugia malayi and Brugia pahangi.
Am J Trop Med Hyg 1982, 31:752—759
2.
Crandall RB, Thompson JP, Connor DH, McGreevy PB,
Crandall CA: Pathology of experimental infection with Brugia
malayi in ferrets: Comparison with occult filariasis in man.
ActaTrop 1984,41:373—381
3.
Crandall RB, Crandall CA, Hines SA, Doyle TJ, Nayar JK:
Peripheral lymphedema in ferrets infected with Brugia ma-
Iayi. Am J Trop Med Hyg 1987, 37:138—142.
4.
Hines SA, Williams JL, Doyle TJ, Crandall RB, Crandall CA,
Nayar JK: Lymphangiography in ferrets infected with Brugia
malayi. Lymphology 1985, 18:1 73—i 74
5.
Thompson JP, Bentley AG, Crandall RB, Crandall CA: The
histology and ultrastructure of the Meyers-Kouwenaar body
in ferrets infected with Brugia malayi. Am J Trop Med Hyg
1984,33:1141—1146
6.
Ottesen EA: Immunological aspects of lymphatic filariasis
and onchocerciasis in man. Trans Roy Soc Trop Med Hyg
1984, 78(suppl):9-18
7.
Connor DH, Palmieri JR, Gibson DW: Pathogenesis of lym-
phatic-filariasis in man. Z Parasitenkd 1986, 72:13—28
8. World Health Organization: Lymphatic pathology and immu-
nopathology in filariasis: Report of the 12th meeting of the
scientific working group on filariasis. TDR/FIL-SWG (12)/
85.3 1985, pp 1—33
9.
Neva FA, Ottesen EA: Tropical (filarial) eosinophilia. New
Eng J Med 1978, 298:1129—1131
10.
Webb JKG, Job CK, Gault EW: Tropical eosinophilia: Dem-
onstration of microfilariae in lung, liver, and lymph nodes.
Lancet 1960, 1:835—842
11.
Thompson JP, Crandall RB, Crandall CA: Brugia malayi: In-
travenous injection of microfilariae in ferrets as an experi-
mental method to study occult filariasis. Exp Parasitol 1985,
60:181—194
12.
Thompson JP, Crandall RB, Doyle TJ, Hines SA, Crandall
CA: Antibody and cellular immune responses to microfilarial
antigens in ferrets experimentally infected with Brugia ma-
Iayi. Z Parasitenkd 1986, 72:525—535
13.
Ottesen EA: Immunopathology of lymphatic filariasis in man.
Springer Semin Immunopathol 1980, 2:373—385.
14.
Ferrets in biomedical research. Lab Animal Sci 1985, 35:
199—318


Acknowledgment

The authors thank Dr. Daniel Connor and the staff of the Depart-
ment of Infectious and Parasitic Disease Pathology at the Armed
Forces Institute of Pathology for continued help with the histopa-
thology.

4

©1999, Janet Becker Rodgers, DVM, MS

All rights reserved.

Comments? Send an email to rodgers@uky.edu