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biologic research.14 The species is commercially available, easily handled, and generally more economic and easier to maintain than the traditional carnivores.


References

1.
Crandall RB, McGreevy PB, Connor DH, Crandall CA, Niel
son JT, McCall JW: The ferret (Mustela putorius furo) as an experimental host for Brugia malayi and Brugia pahangi. Am J Trop Med Hyg 1982, 31:752—759
2.
Crandall RB, Thompson JP, Connor DH, McGreevy PB,
Crandall CA: Pathology of experimental infection with Brugia malayi in ferrets: Comparison with occult filariasis in man. ActaTrop 1984,41:373—381
3.
Crandall RB, Crandall CA, Hines SA, Doyle TJ, Nayar JK:
Peripheral lymphedema in ferrets infected with Brugia maIayi. Am J Trop Med Hyg 1987, 37:138—142.
4.
Hines SA, Williams JL, Doyle TJ, Crandall RB, Crandall CA,
Nayar JK: Lymphangiography in ferrets infected with Brugia malayi. Lymphology 1985, 18:1 73—i 74
5.
Thompson JP, Bentley AG, Crandall RB, Crandall CA: The
histology and ultrastructure of the Meyers-Kouwenaar body in ferrets infected with Brugia malayi. Am J Trop Med Hyg
1984,33:1141—1146
6.
Ottesen EA: Immunological aspects of lymphatic filariasis
and onchocerciasis in man. Trans Roy Soc Trop Med Hyg 1984, 78(suppl):9-18
7.
Connor DH, Palmieri JR, Gibson DW: Pathogenesis of lym
phatic-filariasis in man. Z Parasitenkd 1986, 72:13—28
8. World Health Organization: Lymphatic pathology and immunopathology in filariasis: Report of the 12th meeting of the scientific working group on filariasis. TDR/FIL-SWG (12)/ 85.3 1985, pp 1—33
9.
Neva FA, Ottesen EA: Tropical (filarial) eosinophilia. New
Eng J Med 1978, 298:1129—1131
10.
Webb JKG, Job CK, Gault EW: Tropical eosinophilia: Dem
onstration of microfilariae in lung, liver, and lymph nodes. Lancet 1960, 1:835—842
11.
Thompson JP, Crandall RB, Crandall CA: Brugia malayi: In
travenous injection of microfilariae in ferrets as an experimental method to study occult filariasis. Exp Parasitol 1985, 60:181—194
12.
Thompson JP, Crandall RB, Doyle TJ, Hines SA, Crandall
CA: Antibody and cellular immune responses to microfilarial antigens in ferrets experimentally infected with Brugia maIayi. Z Parasitenkd 1986, 72:525—535
13.
Ottesen EA: Immunopathology of lymphatic filariasis in man.
Springer Semin Immunopathol 1980, 2:373—385.
14.
Ferrets in biomedical research. Lab Animal Sci 1985, 35:
199—318


Acknowledgment

The authors thank Dr. Daniel Connor and the staff of the Department of Infectious and Parasitic Disease Pathology at the Armed Forces Institute of Pathology for continued help with the histopathology.

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©1999, Janet Becker Rodgers, DVM, MS

All rights reserved.

Comments? Send an email to rodgers@uky.edu