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Quiz
on Pharmacology of Injectable Anesthetics
These questions were kindly donated by Dr. Victoria Hampshire, to whom I am very grateful. She sent a CD of material used by USUHS students to prepare for the board exams in 2000, including outlines of the entire blue book on anesthesia complete with questions. Write down your answers and then check the answers at the end. 1. Which of the following is NOT classified as an ultrashort-acting barbiturate: a) Methohexital b) Thiopental c) Pentobarbital d)
Thiamylal 2. Which of the following statements regarding barbiturate anesthesia is FALSE: a) The “glucose effect” causes reanesthetization b) It is associated with a rise in plasma beta-endorphin-like immunoreactivity c) Causes respiratory depression in most species d)
Involves enhancement of gamma-aminobutyric acid-mediated inhibition of
synaptic transmission 3. Hypnotic agents (nonselective CNS depressants) include all but one of the following: a) urethane b) propofol c) tribromoethanol d) fentanyl e)
chloral hydrate 4. In hypnotic doses, the depressant effect of chloral hydrate is at the level of the: a) cerebrum b) medullary centers c) motor nerves d)
sensory nerves 5. IP administration of chloral hydrate in the rat causes: a) rapid hypnosis and analgesia b) adynamic ileus c) increased gastric acid secretion d)
slower onset of action than with the oral route 6. Which of the following is TRUE regarding alpha-chloralose: a) Produces short acting hypnosis b) Provides good levels of analgesia c) Generally has a smooth induction period d)
Has minimal effects on autonomic reflexes 7.
Urethane/alpha chloralose (choose one) provides analgesic levels
sufficient to permit surgery, and is associated with a significant increase in
plasma beta-endorphin-like immunoreactivity. 8. The recommended route of administration for urethane is: a) SC b) IV c) IP d)
PO 9. The following property/properties applies/apply to etomidate: a) Increases cerebral metabolic rate and intracranial pressure b) Is a carboxylated imidazole c) Has good analgesic properties d) Has minimal cardio-respiratory depression e) Repeated doses cause a cumulative effect f) b and d g)
c and e 10. Which of the following agents acts by enhancing GABA activated chloride channels: a) ketamine b) propofol c) fluanisone d)
acepromazine 11. Which of the following statements regarding use of tribromoethanol is FALSE: a) It depresses the CNS and the respiratory and cardiovascular centers b) It provides short term surgical anesthesia in rodents c) It may cause intestinal ileus and death d)
It is metabolized primarily by the kidneys. 12. The high lipid solubility of ketamine results in: a) fast induction and slow recovery b) slow induction and fast recovery c) fast induction and fast recovery d)
slow induction and slow recovery 13. One mode of action of ketamine is by : a) modulating GABAergic transmission b) inhibiting excitatory polysynaptic pathways mediated by N-methylaspartate c) inhibiting presynaptic calcium influx and neurotransmitter release d) selective alpha agonist activity 14. Saffan is classified as a: a) steroid b) cycloheximine c) butyrophenone d) alpha-2 agonist 15. Which of the following statements regarding alpha-2 agonists is FALSE: a) They decrease central noradrenergic neurotransmission b) Inhibition of neurotransmitter release results in sedation, analgesia, and decreased sympathetic tone c) Peripheral actions include vasodilation, diuresis, and decreased GI motility d)
Xylazine causes bradycardia and hypotension in the rat 16. Which of the following do medetomidine and detomidine NOT have in common: a) Both are highly selective alpha-2-agonists b) Both are rapidly absorbed following SC administration in the rat c) SC administration in the rat causes dose dependent sedation, analgesia, and loss of righting reflex d) Both have antinociceptive effects 17. Acepromazine causes which of the following side effects in the dog: a) Decreased arterial pressure b) Increased heart rate c) Increased body temperature d) Increased respiratory rate 18. Which of the following agents is NOT considered a butyrophenone: a) droperidol b) diazepam c) azaperone d) fluanisone 19. Azaperone has been approved for use to control aggressive behavior in which species: a) horse b) rabbit c) dog d) swine 20. Which of the following regarding diazepam and midazolam is true: a) Diazepam is more water soluble and has a shorter duration of action b) Diazepam is more water soluble and has a longer duration of action c) Diazepam is less water soluble and has a shorter duration of action d) Diazepam is less water soluble and has a longer duration of action 21. Which of the following statements regarding local anesthetic agents is TRUE: a) They work by blocking chloride channels thus preventing nerve conduction b) They act by blocking muscarinic receptors c) They act on smaller unmyelinated fibers first d) Procaine causes methemoglobinemia in some species 22. Neuroleptanalgesics are a combination of which 2 types of agents: a) opioid analgesic and tranquilizer b) sedative and tranquilizer c) dissociative anesthetic and tranquilizer d) opioid analgesic and dissociative anesthetic 23. Telazol is nephrotoxic in which species: a) rat b) rabbit c) mouse d) guinea pig
7. urethane Re-read this question 8. b Re-read this question (although the book doesn't actually say it should be given IV, it does discourage IP use; in most cases route is not listed 10. b Re-read this question 11. d Re-read this question 12. c Re-read this question 13. b Re-read this question 14. a Re-read this question 15. c Re-read this question (they cause vasoconstriction, not vasodilation) 16. c Re-read this question 17. a Re-read this question 18. b Re-read this question 19. d Re-read this question 20. d Re-read this question 21. c Re-read this question 22. a Re-read this question 23. b Re-read this question If you didn't get at least 14 correct, you wouldn't have passed if this were the real thing. |
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©1999, Janet Becker Rodgers, DVM, MS All rights reserved. Comments? Send an email to rodgers@uky.edu |